Personally, I think if you haven't used it regularly since the engine was new, one treatment isn't going to do jack. The carbon that builds up on and inside injectors is hard, and a little cleaning agent isn't going to loosen it up. The key is repeated use, then perhaps it will do some cleaning.
Either way, unless your engine is misfiring, you aren't going to notice any difference.
I believe they contain solvents and cleaning agent which clean fuel injectors and other engine components resulting in a more efficient and powerful engine and it depends on how dirty or damaged your fuel injectors are if they aren't bad a fuel a bottle of fuel stem cleaner should do the Jon just fine if not I would say to get an industrial fuel system cleaner or send your injectors out for ultrasonic cleaning
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If you notice a difference of improvement , it worked. How long will improvement last ? This depends on condition of engine .
I have a 1999 Cadillac Deville. I bought a bottle of Fuel System Cleaner to put in with my full tank of gas. I was wondering how well this stuff is supposed to work. My throttle response time seems alot faster than before, but thats all I noticed.